钳形配体2-溴-1,3-双[4-(2-甲基)噁唑基]苯的合成研究

Synthesis of Pincer Ligand of 2-Bromo-1,3-bis(2-methyl-oxazol-4-yl) benzene

以2,6-双(2-溴乙酰基)溴苯和乙酰胺为原料,分别用传统加热法和微波加热法制得了钳形配体2-溴-1,3-双[4-(2-甲基)噁唑基]苯.结果表明,用微波加热法合成目标产物有显著优越性,可使产率从40%提高到85%,同时反应时间从3d缩短到15min.

2,6-Bis（2-bromoacetyl） bromobenzene was heated with acetamide to yield a pincer ligand,2-bromo-1,3-bis（2-methyl-oxazol-4-yl） benzene,with either conventional heating or microwave heating.The result showed that microwave heating is strikingly superior to conventional heating for the synthesis of the target compound.It increased the yield from 40% to 85% and shortened the reaction time from 3 days to 15 min in comparison with conventional heating.