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高密度脂蛋白与心血管保护的研究进展 被引量：5

Recent advance on high-density lipoprotein and its protection of cardiovascular disease
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摘要 多项大规模临床研究显示,血清高密度脂蛋白(HDL)的水平与冠心病存在着密切的联系。HDL胆固醇对心血管的保护作用,体现在可介导胆固醇逆向转运、抗氧化作用、调节内皮功能、抗炎及影响凝血系统等。本文对HDL的结构和代谢进行了回顾,并对其心血管保护作用的新进展进行了综述。 Many large-scale clinical studies show that high-density lipoprotein（HDL） level is closely related to coronary heart disease.Its cardiovascular protection is reflected in reversing cholesterol transport,anti-oxidation,adjusting endothelial function,anti-inflammatory,and exhibiting multiple beneficial effects on the coagulation system.In this paper,the structure and the metabolism of HDL as well as the progress on its protection of cardiovascular disease were reviewed.
作者 路英杰 杨雪 张旭昌 王晓云
机构地区 哈尔滨医科大学附属四院心内科一病房
出处 《心脏杂志》 CAS 2012年第1期120-122,共3页 Chinese Heart Journal
关键词 高密度脂蛋白 心血管保护 冠状动脉疾病 high-density lipoprotein（HDL） Cardiovascular protection Coronary artery disease
分类号 Q513.5 [生物学—生物化学]
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参考文献13

  • 1Wasan KM,Brocks DR,Lee SD,et al.Impact of lipoproteins onthe biological and disposition of hydropholic drugs:implications fordrugs discovery[J].Nat Rev Drug Dicov,2008,7(1):84-89.
  • 2Lee MH,Hammad SM,Semler AJ,et al.HDL3,but not HDL2,stimulates plasminogen activator inhibitor-1 release from adipocytes:the role of sphingosine-1-phosphate[J].Lipid Res,2010,51(9):2619-2628.
  • 3Toth PP.Torcetrapib and atherosclerosis:what happened and wheredo we go from here?[J].Future Lipidol,2007,2:227-284.
  • 4常冠楠,徐新,张社兵.B类Ⅰ型清道夫受体的研究进展[J].中西医结合心脑血管病杂志,2010,8(9):1126-1129. 被引量：5
  • 5Navab M,Reddy ST,Van Lenten BJ,et al.The role of dysfunc-tional HDL in atherosclerosis[J].J Lipid Res,2009,50(Suppl):S145-S149.
  • 6Tolle M,Pawlak A,Schuchardt M,et al.HDL-associated ly-sosphingolipids inhibit NAD(P)H oxidase-dependent monocyte che-moattractant protein-1 production[J].Arterioscler Thromb Vasc Biol,2008,28(8):1542-1548.
  • 7Tamehiro N,Shigemoto-Mogami Y,Kakeya T,et al.Sterol regula-tory element-binding protein-2-and liver X receptor-driven dual pro-moter regulation of hepatic ABC transporter A1 gene expression:mechanism under-lying the unique response to cellular cholesterolstatus[J].Biol Chem,2007,282(29):21090-21099.
  • 8Nissen SE,Tardif JC,Nicholls SJ,et al.Effect of torcetrapib on theprogression of coronary atherosclerosis[J].N Engl J Med,2007,356(13):1304-1316.
  • 9Kastelein JJ,van Leuven SI,Burgess L,et al.Effect of torcetrapibon carotid atherosclerosis in familial hypercholesterolemia[J].NEngl J Med,2007,356(16):1620-1630.
  • 10Bots ML,Visseren FL,Evans GW,et al.Torcetrapib and carotidintima-media thickness in mixed dyslipidaemia(RADIANCE 2 study):a randomised,double-blind trial[J].Lancet,2007,370(9582):153-160.

二级参考文献24

  • 1李莉,张锦,彭阳,刘聪,李强,周一军,孟馨.代谢综合征小鼠肝脏改变及肝脏清道夫受体B1的表达[J].中国老年学杂志,2004,24(12):1168-1171. 被引量：4
  • 2李兰松,李维琪,信学雷,曹旭.大鼠SR-BI胞外域与ApoA-I蛋白相互作用的确认[J].微生物学通报,2006,33(2):68-73. 被引量：1
  • 3胡海,所广军,杨士勇,蔡劬,姜志宏,蔡杏兴,袁作彪,蒋兆彦,张圣道,韩天权.胆固醇结石病人肝脏SRBI及其转录调节因子LRH-1基因表达的研究[J].外科理论与实践,2006,11(4):333-336. 被引量：14
  • 4Pahofer KG. Beyond I.DL - cholesterol : HDL - cholesterol as a target for atherosclerosis prevention [J]. Exp Clin End Diab, 2005, 113(8) :414 -417.
  • 5Mineo C, Yuhanna IS, QuonMJ, et al. High density lipoprotein - induced endothelial nitric - oxide synthase activation is mediated by Akt andMAP kinases[J]. J Biol Chem,2003,278(11) :9142 - 9149.
  • 6Assanasen C, Mineo C, Seetharam D, et a l. Cholesterol binding, efflux,and a PDZ- interacting domain of scavenger receptor- BI mediate HDL- initiated signaling[J]. J Clin Invest,2005,115(4) : 969 - 977.
  • 7Voisset C, Callens N, Blanchard E, et al. High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type Ⅰ[J]. J Biol Chem,2005,280(9):7793 - 7799.
  • 8Grove J, Huby T,Stamataki Z,et al. Scavenger receptor B Ⅰ and B Ⅱ expression levels modulate hepatitis C virus infectivity[J]. J Viro,2007,81(7) :3162 - 3169.
  • 9Philips JA, Rubin EJ,Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection[J]. Science, 2005,309(5738) : 1251 - 1253.
  • 10Ohgami N, Miyazaki A, Sakai M, et al. Advanced glycation end products(AGE)inhibit scavenger receptor class B type I- mediated reverse cholesterol transport: A new crossroad of AGE to cholesterol metabolism[J]. J Atheroscler Thromb, 2003,10 ( 1 ) : 1 - 6.

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心脏杂志
2012年 第1期

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