注射用头孢唑肟钠与维生素B_6注射液的配伍稳定性考察

Study on Compatibility Stability of Ceftizoxime Sodium for Injection and Vitamin B_6 Injection

目的:考察注射用头孢唑肟钠与维生素B6注射液的配伍稳定性。方法:模拟临床用药,2种药采用0.9%氯化钠注射液和5%葡萄糖注射液作为溶媒配伍后,考察24h内不同浓度的2种药混合后配伍溶液的外观变化,并通过高效液相色谱法检测主药成分的含量变化。结果:在室温(25℃)下,2种药配伍后产生大量白色沉淀,且主药含量明显降低。结论:二者存在配伍禁忌。与其他文献报道的在5%葡萄糖溶液中稳定的结论不符,《400种中西药注射液临床配伍应用检索表》中注射用头孢唑肟钠与维生素B6注射液无配伍禁忌的论述不确切。

OBJECTIVE： To investigate the compatibility stability of Ceftizoxime sodium for injection and Vitamin B6 injection. METHODS： 0.9% Sodium chloride injection and 5% Glucose injection were used as solvent in clinical simulated drug use. The appearance change of mixture was observed within 24 h after the two drugs in different concentrations were mixed, and HPLC was used to determine the content change of main composition. RESULTS： At room temperature （25 ~C ）, the two drugs produced a great number of white precipitate after compatibility; the main component was significantly reduced. CONCLUSION： There is incompatibility between the two drugs. The results of study are not in line with the conclusion that the mixture is stable in 5% Glucose solution in other literature reports. The conclusion that there is no drugs incompatibility in compatibility of Ceflizoxime sodium with Vitamin B6 injection hasn＇ t been described exactly in Retrieval Table for Clinical Application Compatibility of 400 TCM and Western Medicine Injections.