胃癌及其癌旁黏膜中维生素D受体的表达

Expression of vitamin D receptor in gastric carcinoma and normal mucosa adjacent to carcinoma

目的探讨胃癌组织中维生素D受体(VDR)的表达,并与癌旁正常胃黏膜组织比较。方法采用免疫组化方法,检测75例胃癌组织和癌旁正常胃黏膜组织中VDR表达。结果胃癌组织中VDR表达显著低于正常胃黏膜(P<0.05)。癌组织中VDR的表达在不同年龄、性别、TNM分期、组织学分型、浸润深度、淋巴结转移之间差异无统计学意义。VDR表达与癌组织分化程度有关,高、中、低分化3组VDR表达依次降低,且差异有统计学意义(P<0.05)。结论 VDR表达可以作为判断胃癌分化程度的依据之一。

Objective To examine expression of vitamin D receptor （VDR） in gastric cancer and normal mucosa adjacent to cancer. Methods VDR expression in tumor tissue and normal mucosa was detected by immunohistochemistry for 75 cases of gastric carcinoma. Results VDR expression in gastric tumor was significantly lower than that in normal mucosa （P 〈 0.05）. In constrast, VDR expression did not show significant correlation with gender, age, histological classification, TNM stage, or infiltration depth. Yet, a significant correlation was found between VDR expression and carcinoma differentiation status： well differentiated carcinoma had the highest level of VDR expression （ P 〈 0.05 ） among all stages. Conelusions VDR expression can be considered as a marker of gastric cancer differentiation.