摘要
目的:探讨胰岛素样生长因子-1(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)在大鼠视网膜缺血再灌注损伤(RIRI)后的表达规律及相关性。方法:建立大鼠视网膜缺血再灌注模型,应用免疫组织化学法检测大鼠RIRI后视网膜组织IGF-1和IGFBP-3表达的变化规律,对两者进行相关性分析。结果:正常视网膜组织IGF-1和IGFBP-3即有轻微表达,IGF-1在缺血再灌注后6h表达明显增高,72h达到高峰,IGFBP-3在缺血再灌注后12h表达明显增高,72h达到高峰,且二者具有相关性。结论:IGF-1和IGFBP-3表达与RIRI有关,两者呈正相关。
AIM：To investigate the expression pattern and correlation of insulin-like growth factor-1 （IGF-1）and its binding protein-3（IGFBP-3） in the ischemia-reperfusion in rats. METHODS：The models of retinal ischemia-reperfusion in rats were made.In order to analyze the correlation and expression between IGF-1 and IGFBP-3 in retinal ischemia-reperfusion model,immunohistochemical method was used. RESULTS：In the normal retina,IGF-1 and IGFBP-3 were slightly expressed,while in retinal ischemia-reperfusion group,the expression of IGF-1 ascended obviously at 6 hours,reached peak at 72 hours; the expression of IGFBP-3 ascended obviously at 12 hours,reached peak at 72 hours,and the two had a collaborative relationship. CONCLUSION： IGF-1 and IGFBP-3 expression are closely related to retinal ischemia-reperfusion injury,and have a positive correlation.
出处
《国际眼科杂志》
CAS
2012年第3期413-415,共3页
International Eye Science
