胰岛素在糖尿病视网膜病变中的研究进展

Research progress of insulin in diabetic retinopathy

胰岛素是人体内唯一降血糖的激素,也是治疗糖尿病的一线药物。近期研究发现大剂量应用胰岛素治疗糖尿病已成为糖尿病视网膜病变进展的独立危险因素之一。研究显示胰岛素通过促进细胞增殖、破坏血-视网膜屏障、促进新生血管的形成、影响谷氨酸代谢及诱导氧自由基的产生等促进糖尿病视网膜病变的发展。

Insulin is the only hypoglycemic hormone, and the primary drug to treat diabetes. Recent studies found that high-dose insulin treatment of diabetes has become one of independent risk factors of progressing of diabetic retinopathy. Studies have shown that insulin can promote the development of diabetic retinopathy by promoting cell proliferation, destroying the blood-retinal barrier, promoting the proliferation of new vessels, affecting glutamate metabolism and inducting oxygen free radicals, etc.