TGF-α与IGF-Ⅱ在血液透析中的检测及其临床意义

Expression of transforming growth factor-a and insulinlike growth factor in homedialysis patients and its application

目的：研究多肽生长因子ＴＧＦ－α与ＩＧＦ－Ⅱ在长期血透（ＨＤ）患者血清及体液中的表达特征。方法：采用放射免疫分析法，检测４５例维持性ＨＤ患者血清及１２ｈ尿液中ＴＧＦ－α与ＩＧＦ－Ⅱ的水平。结果：ＴＧＦ－α水平明显低于正常组，ＩＧＦ－Ⅱ则明显高于正常组。ＨＤ后血清中两项指标水平均明显高于ＨＤ前，测定１２ｈ尿液ＴＧＦ－α和ＩＧＦ－Ⅱ含量均较正常对照组增高明显（Ｐ＜０．０５；Ｐ＜０．０１）。结论：尿毒症状态或血透过程透析膜等因素可激活单核细胞，导致ＴＧＦ－α和ＩＧＦ－Ⅱ的产生增多。

Objective: To study the expression characteristic of TGF-a and IGF-II in maintenance homedialysis patients. Methods:Com-a and IGF-II levels in sera and 12 h urine of 45 maintenance homedialysis patients were detected by radio-immunity analysis. Results: Compared with normal control, serum TGF-a decreased significantly (P < 0.01), and IGF-II increased significantly. Both of TGF-a and IGF-IIlevels in sera and 12 h urine increased significantly after homedialysis (P < 0.05, P < 0.01). Conclusinon: It suggested that the status ofurinaemia and dialyser can stimulate mononuclear cell to synthesis more TGF-a and IGF-II.