颌骨骨肉瘤临床病理学观察及文献复习

Osteosarcoma of the Jaw Clinicopathological investigation and review of the literature.

本文复习两例颌骨骨肉瘤临床、病理组织学及免疫组织化学表现,并讨论这一少见病变的组织学诊断要点。认为应仔细寻找最有力的诊断依据即异形性骨母细胞直接产生杂乱无章、不成熟交织骨及骨样组织,即肿瘤性骨。肿瘤性骨母细胞可呈碱性磷酸酶阳性反应。此外,进行性面部肿胀、肿瘤局部侵犯。

Two cases of Osteosarcoma (OS) of the jaw were reviewed here to evaluate the clinical, histological and immunohistochemical characters. Essentials of histological diagnosis for this rare lesion were discussed here. The principal clue to diagnosis is disorderly arranged and undifferenciated tumorous woven bone and osteoid produced directly by anaplastic osteoblasts that may be possitive for ALP. The patient's clinical situation will be also helpful in diagnosis such as progressively facial swelling with or without pain, local invasion of the tumor, elevated blood ALP, and detailed radiological presentation especially with CT scanning.