平阳霉素和地塞米松及鱼肝油酸钠联合注射治疗颌面部海绵状血管瘤

Effects of Pinyangmycin, Dexamethasonum and Sodium Morrhuate Injection on Treatment of Cavernous Hemangioma

目的 :评价平阳霉素、地塞米松和鱼肝油酸钠联合注射治疗颌面部海绵状血管瘤的疗效。方法 :采用平阳霉素、地塞米松和鱼肝油酸钠联合瘤内注射治疗 115例颌面部海绵状血管瘤患者。 5～ 7d注射 1次 ,3～ 5次为 1个疗程。结果 :115例患者平均疗程 2 1d ,治疗完成后经 6～ 2 4个月随访 ,治愈和基本治愈达 96 5 2 % ,有效率为 10 0 %。结论 :平阳霉素、地塞米松和鱼肝油酸钠联合注射治疗颌面部海绵状血管瘤安全、简便 ,疗效高 ,疗程短。

Objective: To evaluate the effects of Pinyangmycin, Dexamethasonum and Sodium morrhuate injected homochronouly on treatment of cavernous hemangioma in maxillofacial regions. Methods: The medical records of 115 patients with cavernous hemangioma in maxillofacial regions between September, 1996 and September, 1998 were reviewed. Fifty of the patients were men, and 65 were women, with a ratio of 1∶1 3. The age of the patients was from 4 months old to 45 years old. 73 of the hemangioma bodies were sited in maxillofacial regions, 42 were sited in oral cavity. The sizes of the lesions varied from 1cm×1cm to 5cm×8cm. Treatment procedure: ①Preparation: 8mg Pinyangmycin was dissolved in 5mg/ml Dexamethasonum and in 4ml of 1% procain which were ready for use; ②Injection: 1～5ml (Pinyangmycin 1 6～8 0mg) of mixed solution was first injected to the hemangioma, then followed by an injection of 0 5～2 0ml Sodium morrhuate according to local appearance, size of the tumor and patient′s age. Generally, the amount of each injection should not be over 8mg Pinyangmycin. If the tumor did not subside after an injection, another injection might be repeated every 5～7 days, and this process might be repeated 3～5 times. The total dose of Pinyangmycin should not be over 40mg. Results: 115 patients were followed up for 6～24 months. 81 of 115 (70 43%) cases were recovered, and 30 (26 09%) cases were basically recovered. 4 (3 48%) cases got improvement. The recovery rate were 96 52%, and the total efficiency was 100%. Conclusion: This method may be a safe, simple and effective therapy to cavernous hemangioma in maxillofacial regions.