补阳还五汤抗家兔动脉粥样硬化形成的实验研究

“Bu-yang huanwu tang” ~① inhibited the pathogentic process of atherosclerosis induced by cholesterol-rich diet in rabbits

在家兔动脉粥样硬化的模型上观察补阳还五汤抗动脉粥样硬化的作用。结果表明 :该汤剂具有明显的降低血清总胆固醇和甘油三酯的作用 ,显著延缓主动脉及腹主动脉粥样硬化斑块的形成、减缓冠脉血管受累的数目和程度。还具有升高 6 keto PGF1α和降低vWF的作用 ,但对血浆中ET的含量并无影响。提示补阳还五汤的抗动脉粥样硬化与抗血栓形成的作用有关。

Background and objective: “Bu yang huanwu tang” ①, a decoction of Chinese herbs widely used in the treatment for cardio and cerebro vascular diseases, has been demonstrated to be able to inhibit platelet adhesion and aggregation, to lower blood lipids, to regulate vascular tone from animal experiments. The aim of this study is to determine whether this decoction inhibits the pathogentic process of atherosclerosis induced by cholesterol rich diet in rabbits. Methods: Three groups of rabbits received the following different diets for 9 weeks: 1. standard diet; 2. atherogenic diet(standard diet plus 1% cholesterol and 3.3% fat); 3. atherogenic diet plus this decoction(5?g·kg -1 ·d -1 ). Plasma lipids, 6 keto PGF 1α , endothelin levels were detected and the histological atherosclerotic changes were evaluated. Results: This decoction inhibited the progression of aortic and abdominal aortic intimal plaques and reduced aortic intimal thickening. Conclusion: The anti atherogenic mechanism might be related to the decrease of plasma cholesterol and triglycerides and the increase of PGI 2. The facts suggest that “Bu yang huanwu tang” has antiatherogenic and antithrombotic effects. [