摘要
应用酶联免疫吸附法 (ELISA)检测多发性硬化 (MS)患者血清及脑脊液 (CSF)中的可溶性Fas分子(sFas) ,对照组为其他神经病组 (OND)及健康人 (HC)。结果表明 :MS患者组血清及CSF中sFas高于OND及HC组 ,且MS患者活动期sFas高于缓解期。提示sFas可能与MS的临床活跃有关 ,Fas分子可能在MS的免疫病理反应中扮演重要角色。
We examined the levels of the soluble form of the Fas(sFas) in the cerebrospinal fluids(CSF) and the sera of patients with multiple sclerosis(MS) using an enzyme linked immunosorbent assay(ELISA). The levels of sera and CSF sFas were significantly higher in MS patients than that in other neurological diseases(OND) group and healthy control(HC); MS patients in the active stage had more sFas molecule than that in the inactive stage. It suggests that sera and CSF sFas may be related to clinical activity in patients with MS, and that sFas may play an important role in the pathogenesis of the MS. [
出处
《湖南医科大学学报》
CSCD
2000年第1期39-41,共3页
Bulletin of Hunan Medical University
关键词
多发性硬化症
血清
脑脊液
SFAS
multiple sclerosis
soluble Fas molecule *
serum
cerebrospinal fluids
