降钙素在支气管扩张症肺组织表达的临床意义

Clinical significance of calcitonin expression in lung tissue with bronchiectasis

目的 :为了解支气管扩张症肺组织降钙素 (CT)抗原表达水平与其病变特点的关系。方法 :应用免疫组化方法定量分析支气管扩张组和非支气管扩张组近肺组织 10cm气道上皮长度内CT阳性的肺神经内分泌细胞(PNEC)数。结果 :支气管扩张症组肺组织内CT阳性细胞数为 (67 5 9± 10 5 7)个 ,非支气管扩张组肺组织内CT阳性细胞数仅为 (5 4 8± 1 0 6)个 (P <0 .0 0 1)。结论 :支气管扩张症肺组织内高水平的CT表达可能与支气管扩张症慢性炎性病理形态学改变有关。

Objective: To investigate the relation between the pathologic feature of bronchiectasis and the expression of calcitonin(CT) protein within pulmonary neuroendocrine cells(PNEC) in bronchiectasis. Method: CT expression of PNEC was detected using immunohistochemistry(SP method) and quantitative analysis was completed by counting CT positive cell number on per 10?cm length of epithelium. Result: CT positive PNEC were found both at all levels of airway tree in all 37 cases of bronchiectasis and 10 cases of control, but none were found in alveolar ducts and alveoli. In bronchiectasis, CT positive PNEC was 67.59±10.57 per 10?cm length of epithelium, and in control group 5.48±1.06. Statistical analysis revealed a significant difference between bronchiectasis and control(P<0.001). Conclusion: There was a high level CT expression in bronchiectasis. The PNEC hyperplasia may play a role in the chronic inflammation of bronchiectasis. [