口腔粘膜下纤维性变微血管形态定量分析

A morphometric study on the microvessel in oral submucous fibrosis

以CD34 为标志物对 2 7例早、中、晚期口腔粘膜下纤维性变 (OSF)组织中的微血管作免疫组化染色 ,并采用微机图像分析系统定量检测了微血管计数、数密度、微血管面积和面密度。结果表明 :OSF组织中 ,早期微血管增生 ;中、晚期微血管数量减少、面积缩小 ;对其发生的病理机制进行了分析。

To investigate the pathologic change of the microvessel in oral submucoous fibrosis(OSF), the pathologic buccal tissues of 27 patients with OSF were studied by using immunochemical method. Microvessel quantity(MVQ), quantity density(QD), microvessel area(MVA) and area density(AD) were determined by means of computer aided image analysis system. The results showed the increase in MVQ and QD in the early stage and the decrease in MVQ, QD, MVA and AD in the middle stage and the late stage. The authors concluded that presence of microvessel hyperplasia occurred in the early stage of OSF. [