白介素-1在骨关节炎发病机制中的研究进展

Research progression of interleukin-1 in the pathogenesis of osteoarthritis

骨关节炎(osteoarthritis,OA)是临床常见的关节病,严重影响患者的身体健康和生活质量,给家庭和社会带来了巨大的经济负担。OA的病因及发病机制至今尚未完全明确,但细胞因子在其发病机制的研究中越来越受到重视,尤以IL-1被认为是骨性关节炎发生发展中最核心的因子。近年来,许多临床试验把IL-1作为治疗骨关节炎的靶点,为OA的治疗提供新的方法。本文就IL-1参与OA软骨破坏的机制做一综述。

Osteoarthritis is a common joint disease,which seriously affects the patient＇s health and quality of life. It results in substantial social and economic costs. Etiology and pathogenesis of OA is still not completely clear,but people paid more attention on Cytokines,especially IL-1,which is considered as core factor in the development of OA. In recent years,many clinical trials considered IL-1 as a target treatment for OA. It provided a new treatment method. This article is to overview the mechanism of IL-1 in OA cartilage damage.