摘要
目的：探讨内源性ＮＯ在应激状态下胃粘膜耐受性细胞保护中的作用及其可能的机制。方法：采用重复浸水束缚应激（ＷＲＳ）制作动物模型，动态监测胃粘膜血流量（ＧＭＢＦ）、血浆及粘膜内ＮＯ含量的变化。结果：重复应激伴有ＧＭＢＦ的上升以及血浆、粘膜内ＮＯ含量的增高，且ＧＭＢＦ与血浆、粘膜内ＮＯ含量之间呈显著正相关，但它们与粘膜损伤之间呈显著负相关。
Objective: To study the role of endogenous NO in gastric mucosal tolerant cytoprotection under stress and the possible mechanism. Methods: SD rats were exposed to single or repeated WRS for 4 h every other day for up to 6 days, during which GMBF was measured using LDF 3 Flowmeter. NO levels in plasma and gastric mucosa were monitored by Griess reaction. Results: Gastric tolerant cytoprotection was accompanied by increased GMBF and NO levels in plasma and gastric mucosa. There was a positive proportion between GMBF and NO contents in plasma and gastric mucosa. Inversely, negative relationship was found between GMBF and NO levels in plasma and gastric mucosa and mucosal lesions. Conclusion: By regulating GMBF, endogenous NO might play an important role in the gastric mucosal tolerant cytoprotection under stress
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第1期7-9,共3页
Academic Journal of Second Military Medical University
基金
军队医药卫生杰出中青年人才科研基金!资助项目(1996 卫科训字95 号)
关键词
应激
细胞保护
耐受性
一氧化氮
胃溃疡
stress
gastric mucosa
cytoprotection,tolerance
nitric oxide
