摘要
目的：探讨创伤应激时大鼠胃动力的变化以及胃肠动力调节相关神经肽血管活性肠肽（ＶＩＰ）及胆囊收缩素－８（ＣＣＫ－８） 对它的影响。方法：于大鼠胃窦部缝置应力传感器，将大鼠双侧后肢骨膝关节以上钳断，制备应激模型。记录应激前后大鼠胃动力的变化及血浆内ＶＩＰ和ＣＣＫ－８ 含量的改变，观察应激前后静脉插管内给予ＶＩＰ和ＣＣＫ－８ 后胃动力变化。结果：正常大鼠禁食状态，胃运动呈规则的相对静止期、收缩期交替的变化。ＶＩＰ可抑制正常大鼠胃运动，ＣＣＫ－８明显加强胃的收缩。应激使大鼠胃窦的规则收缩消失、运动加强；大鼠血浆内ＶＩＰ含量在应激后１，２ ｈ 显著升高， ＣＣＫ－８ 含量于应激后即刻升高，随后恢复正常。相同剂量的ＶＩＰ对增强的胃运动有明显的抑制效应。结论：创伤应激可致大鼠胃动力紊乱及体内胃肠动力调节相关神经肽ＶＩＰ，ＣＣＫ－８分泌改变，ＶＩＰ对增强的胃动力有抑制作用。
Objective: To determine the effects of traumatic stress and the influence of associated neuropeptides (VIP,CCK 8) on gastric motility in rats. Methods: With strain gauge transducers placed on antrum of rats, the stress model were made by fracturing the hind legs of rats beyond the knee joints. Gastric motility and the contents change of VIP and CCK 8 in plasma was recorded before and after stress, exogenous peptides (VIP,CCK 8) were intravenously administrated to determine the gastric motor response to them. Results: In fasted rats, before stress gastric motor activity became regular in resting and contractile states. VIP inhibited whereas CCK 8 enhanced gastric motor. The regularity of gastric motor was destroyed and motor activity increased after stress.Plasma level of VIP rose in 1 and 2 hour whereas contents of CCK 8 was immediately increased then returned to normal after stress. VIP inhibited the enhanced gastric motility at the same dose. Conclusion: Traumatic stress disturbs gastric motility and secretion of associated neuropeptides in rats. VIP has inhibitory effect on enhanced gastric motility.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第1期13-15,共3页
Academic Journal of Second Military Medical University
基金
军队医药卫生杰出中青年人才科研基金!资助项目(1996 卫科训字95 号)
