三叉神经痛患者血液P物质及其临床意义

Clinical significance of substance P in blood of the patients with trigeminal neuralgia

目的：观察三叉神经痛发作时局部是否有Ｐ物质参与，加深对三叉神经痛发病机制的认识。方法：三叉神经痛患者１６ 例，正常自愿者１０ 名，用放射免疫测定法检测疼痛发作时患侧颈外静脉血、肘静脉血及术后患侧颈外静脉血中Ｐ物质含量，正常自愿者颈外静脉血中Ｐ物质的含量作为正常对照。结果：疼痛发作时患侧颈外静脉血中的Ｐ物质含量明显高于患者肘静脉血、术后患侧颈外静脉血及正常自愿者颈外静脉血中的Ｐ物质含量。结论：三叉神经痛发作时局部确有Ｐ物质参与。

Objective: To observe whether substance P participate in the attack of trigeminal neuralgia, and get a deeper understanding about its pathogenetic mechanism. Methods: Sixteen patients were studied. During the attacks the venous blood was sampled from both the external jugular vein and cubital fossa vein ipsilateral to the pain, after operations the venous blood from the external jugular vein was sampled again. The external jugular vein blood of 10 normal volunteers was collected as control. Plasma levels of substance P were determined using sensitive radioimmunoassays. Results: During the attacks of trigeminal neuralgia the levels of substance P in the external jugular vein blood were significantly higher than that in the cubital fossa vein blood, postoperative external jugular vein blood and the external jugular vein blood of normal volunteers. Conclusion: Substance P indeed participates in the attack of trigeminal neuralgia in the local region. Fast release and exhaustion of the excessive substance P may be related to the intense paroxysmal pain of trigeminal neuralgia.