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龈沟液中抑瘤素M水平与牙周状态的关系

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摘要 目的:先前有研究表明慢性牙周炎患者龈沟液中抑瘤素M(OSM)的水平升高。目前没有牙龈炎患者的龈沟液中OSM水平的相关研究。本实验检测了牙龈炎和慢性牙周炎患者龈沟液中OSM水平,以及慢性牙周炎患者牙周治疗后龈沟液中OSM的水平变化。方法:根据牙龈指数(GI),探诊深度(PD),附着丧失(CAL),把60个个体分成3组,健康组(group Ⅰ),牙龈炎组(group Ⅱ),慢性牙周炎组(group Ⅲ),第4组(group Ⅳ)为来源于慢性牙周炎组的20个个体进行为期8周的牙周治疗。采用酶联免疫吸附试验(ELISA)检测龈沟液标本中的OSM水平。结果:慢性牙周炎组龈沟液中OSM的水平最高0.81±0.33pg/μl,健康组0.0689±0.022pg/μl,治疗后的慢性牙周炎组0.0943±0.037pg/μl,牙龈炎组0.125±0.023pg/μl。结论:龈沟液中OSM水平升高与PD和CAL正相关,可能成为反映牙周组织破坏程度的生物指征。
出处 《中国社区医师(医学专业)》 2012年第5期86-87,共2页
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