老年男性心力衰竭患者睾酮和雌二醇及去甲肾上腺素水平与心功能的关系

Correlation between the levels of testosterone,estradiol,noradrenaline and the heart function in the aged male patients with chronic heart failure

目的探讨老年男性心力衰竭患者血清睾酮(T)、雌二醇(E_2)及去甲肾上腺素(NE)水平与心功能的关系。方法采用酶联免疫吸附试验(ELISA)测定100例老年男性心衰患者血清T、E_2及NE水平,并以100名同期同龄健康男性为对照组。结果 (1)心衰组血清T水平显著低于对照组,且心功能Ⅱ、Ⅲ、Ⅳ级组的T水平呈进行性下降趋势(P<0.01),NE水平则随心衰严重程度逐级递增;(2)血清E_2水平与心功能无显著相关性(P>0.05)。结论血清T、NE水平测定可用于老年男性心衰患者的心功能评价和对心衰预后的判断。

Objective To explore the correlation between the serum levels of testosterone （T）, estradio （E2 ）, noradrenaline （NE） and the heart function in aged male patients with chronic heart failure （CHF）. Methods The serum levels of T, E2 and NE levels were determined by ELISA in 100 aged male patients with CHF and 100 ages matched healthy individuals. Results （ 1 ） Serum T in CHF group was significantly lower than that in the control group; The T level in CHF patients with II , III, IV level of cardiac function was step down （P 〈 0. 01 ）, NE level with severity heart failure was gradually increasing; （2） The serum E2 level was no significantly correlated with cardiac function （P 〉 0. 05 ）. Conclusion The determination of serum T, NE level can be used for heart function evaluation of older male patients with heart failure.