支原体肺炎患儿47例急性期血清白细胞介素6及C反应蛋白变化的分析

Analysis of the changes of serum levels of interleukin-6 and C reaction protein in 47 children with mycoplas- ma pneumoniae pneumonia at acute stage

目的探讨白细胞介素6(IL-6)和C反应蛋白(12RP)在小儿支原体肺炎(MPP)的发生、发展中的重要作用,以判断病情的严重程度及预后。方法 47例已确诊为MPP的急性期患儿,根据心肌酶谱的测定结果,分为心肌损伤组28例和无心肌损伤组19例,另选28名健康儿童为对照组。分别采集空腹静脉血,用ELISA方法测定血清IL-6,透射比浊法测定CRP的水平。结果肺炎支原体感染组血清IL-6和CRP较对照组升高,差异有统计学意义(P<0.01),并且心肌损伤组显著高于无心肌损伤组(P<0.01),血清IL-6与CRP水平呈中度正相关(r=0.690,P<0.001)。结论肺炎支原体(MP)感染患儿急性期IL-6和CRP明显升高,且二者成正相关,合并心肌损伤者高于无心肌损伤者,提示其水平变化程度可能与病情轻重相关。

Objective To explore the important role of interleukin-6 （IL-6） and C reaction protein （CRP） in onset and development of myeoplasma pneumonine pneumonia （MPP） and judge the severity and prognosis by studying the changes of IL-6 and CRP in peripheral blood of children with MPP at acute stage. Methods Forty-seven children with MPP were divided into myocardial injury group and non-myocardial injury group according to myocardial enzymogram. The serum levels of IL-6 with the method of enzyme-linked immunosorbent assay （ELISA） and CRP with turbidimetric assay in automatic biochemical analyzer were determined in those patiets as well as 28 controls. Results The levels of serum IL-6 and CRP in children with MPP were higher than those in the controls （P 〈0.01 ）. The levels of serum IL-6 and CRP in the myocardial injury group were higher than those in the non-myocardial injury group （ P 〈 0. 01 ）. The level of serum IL-6 was positively correlated with the level of serum CRP （ r = 0. 690, P 〈 0. 001 ）. Condusion The eoncertration of IL-6 and CRP in children with MPP at acute stage increased significantly and there were significant positive correlation between them, indicating acute phase of MPP in children associated with a clear inflammatory response. Furthermore the levels of IL-6 and CRP in children with myocardial injury were higher than those without myocardial injury, suggesting that the changes of levels of IL-6 and CRP may be associated with disease severity.