maspin基因的抑癌作用机制及其在肝癌中作用的研究进展

Progress on maspin gene in tumor suppression and liver cancer

maspin是一种肿瘤抑制基因,该基因具有诱导肿瘤细胞凋亡,抑制肿瘤细胞运动、侵袭、转移和肿瘤新生血管生成等作用。maspin基因表达受体内多条途径的精确调控,但其在肝癌中作用的研究较少。该文就maspin基因的抑癌作用机制及其在肝癌中作用的研究进展作一综述。

maspin is a tumor suppressive gene and plays an important role in promoting tumor cells apopto- sis, suppressing tumor cells mobility , invasive, metastasis and angiogenesis. The expression of maspin gene is precisely controlled by several pathways. But the role of maspin in liver cancer is poorly investigated. In the paper,the progress on the mechanisim of tumor suppression of maspin gene and its role in liver cancer were reyiewed.