Iriomoteolide-1b中C(13)-C(23)片段的立体选择性合成

A Stereoselective Synthesis of the C(13)-C(23)Fragment of Iriomoteolide-1b

采用已知文献报道的化合物为起始原料,以不对称Evans-aldol反应和Julia-Kocienski成烯反应为关键步骤,对大环内酯化合物Iriomoteolide-1b的C(13)-C(23)片段结构进行了合成研究.全文使用普通而廉价的原材料或者试剂,采用常规的容易操作的反应条件,实验成本比较低,并且以13步13%的产率得到了C(13)-C(23)片段结构.

A stereoselective synthesis of C（13）-C（23） subunit of iriomoteolide-1b has been achieved in 13% yield over 13 steps from the known diol,exploiting the asymmetric aldol reaction and the Julia-Kocienski olefination as the key steps.In order to reduce the cost of the synthesis we adopted usual reactions and used inexpensive reagents through the synthesis strategy.