摘要
越来越多的研究表明CXCR4与CXCR7在肿瘤的发生发展过程中发挥着重要作用,CXCR4与CXCR7作为G蛋白藕联受体介导的信号传导通路及其在胞内激化级联信号通路与肿瘤发生发展的分子机制有密切关系。本文将对它们各自介导的信号通路及其在胞内的级联信号通路与肿瘤细胞的生长、增殖、黏附和迁移等生物学特性的关系进行综述。
More and more research results have demonstrated that CXCR4 and CXCR7 as G-protein coupled receptors（GPCRs） are important mediators and cascaders of cellular signal transduction,which is closely revelent to tumorigenesis.In this paper we review the relationship between their respective signaling modules,the cascade of intracellular signal pathways and biological features of tumor,such as growth,proliferation,adhesion,migration and so on.
出处
《基础医学与临床》
CSCD
北大核心
2012年第3期349-353,共5页
Basic and Clinical Medicine
