药物治疗高龄患者阵发性心房颤动的1年随访

Drugs for elderly patients with paroxysmal atrial fibrillation l year follow-up

目的 观察胺碘酮、普罗帕酮、索他洛尔治疗老年阵发性心房颤动的疗效.方法 82例年龄85岁及以上高龄的阵发性心房颤动患者随机分为胺碘酮组 （39例）、普罗帕酮组 （21例） 和索他洛尔 （22 例） 组,分别选用胺碘酮、普罗帕酮、索他洛尔进行复律治疗.结果 3组患者服药后48h内有效率分别为 96%、35%、17%,组间差异有统计学意义.1年随访有效率分别为 86%、25%、1l%,组间差异有统计学意义.3组药物的不良反应发生率分别为 26%、15%、10%,差异有统计学意义;胺碘酮严重不良反应多见.结论 3种药物中胺碘酮治疗高龄患者阵发性心房颤动的疗效最佳,但不良反应明显,其他两种药物有一定疗效,但不良反应相对较少.

Objective To investigate the efficacy of propafenone, admiodarane, sotalol in treating and preventing of paroxysmal atrial fibrillation （PAF）. Methods 82 elderly patients with atrial fibrillation were randomly divided into propa- fenone （n=39）, admiodarane （n=21） and sotalol groups （n=22）. Results The recovery rates within 48 hours after treatment in propafenone, admiodarane and sotalol group were 96%, 35% and 17%, respectively. There was significant difference among different groups. The occurrence rates of adverse reactions in the propafenone, admiodarane and sotalol group were 26%, 15% and 10%, respectively. There was significant difference. Conclusion Of three drugs, amiodarone has the best efficacy in treating elderly patients with paroxysmal atrial fibrillation, but has significant side effects, whereas the others have some treatment outcomes with relatively few side effects.