摘要
3-溴-1-(3-氯-2-吡啶基)-4,5-二氢-1H-吡唑-5-甲酸(M-4)与酰卤化试剂反应可同时将吡唑啉环氧化为吡唑环制得3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酰氯中间体(M-5),该酰氯与取代苯胺无缚酸剂存在下制得溴氰虫酰胺。该路线缩短了反应步骤,减少了氧化剂的使用。
The intermediate 3-bromo-1-（3-chloropyridin-2-yl）-4,5-dihydro-lH-pyrazole-5-carboxylic acid （M-4） reacted with halogenation reagents, simultaneously the pyrazoline ring oxidized to pyrazole ring, to get the intermediate 3-bromo-l-（3-chloropyridin-2-yl）-1H-pyrazole-5-carbonyl chloride （M-5）. Using M-5 reacted with substituted anthranilamide without acid scavengers, cyantraniliprole was provided in high yield. This method simplified the reaction steps, and reduced the use of oxidant.
出处
《现代农药》
CAS
2012年第1期22-24,29,共4页
MODERN AGROCHEMICALS
关键词
溴氰虫酰胺
合成
方法
cyantraniliprole
synthesis
method
