水通道蛋白-4与脑膜瘤瘤周水肿的关系

Relationship between the expression of aquaporin-4 in meningiomas and peritumorous brain edema

目的研究水通道蛋白-4(AQP-4)在脑膜瘤中的表达与瘤周水肿(PTBE)的关系。方法选择脑膜瘤患者70例,计算水肿指数,免疫组化检测脑膜瘤中AQP-4、血管内皮生长因子(VEGF)表达水平,分析AQP-4、VEGF与脑膜瘤PTBE之间的关系。结果本组脑膜瘤PTBE发生率62.9%(44/70)。AQP-4和VEGF的表达阳性率在无水肿组分别为38.5%(10/26)和65.4%(17/26)。而在水肿组则分别为90.9%(40/44)和93.2%(41/44);AQP-4和VEGF在脑膜瘤中的表达水平,两组间相差显著(P<0.01)。AQP-4和VEGF表达水平均与脑膜瘤PTBE的程度呈正相关(P<0.05)。结论 AQP4、VEGF在脑膜瘤中的高表达可能参与了其PTBE的形成。

Objective To study the relationship of the expression of aquaporin-4 （AQP-4） in the meningiomas with the peritumor brain edema （PTBE）. Methods The edema index was calculated according to the preoperative head MRI in 70 patients with meningiomas, in whieh the expressions of AQP-4 and vascular endothelial growth factor （VEGF） were detected by immunohistochemical method. The relationship of the expressions of AQP-4 and VEGF in the meningiomas with the peritumor brain edema was analyzed. Results The＇ oecurrent rate of PTBE was 62.9%（44/70） in these 70 patients with meningiomas. The positive rates of AQP-4 and VEGF expressions were 38.5% （10/26） and 65.4% （17/26） respectively in the no edema group and 90.9% （40/44） and 93.2% （41/44） respectively in the edema group. There were significant difference in the positive rates of AQP-4 and VEGF between both the edema and no edema groups （P〈0.01）. The levels of AQP-4 and VEGF expressions were positively related to the severity of the meningioma PTBE （P〈0.05）. Conclusion It is suggested that up-regulation of the levels of AQP-4 and VEGF expressions in the meningiomas may participate in the formation of the meningioma PTBE.