胃癌患者血清可溶性细胞间粘附分子-1检测的临床意义

Serum Levels of Intercellular Adhesion Molecule-1 in Patients with Gastric Cancer

目的 :探讨血清可溶性细胞间粘附分子 -1(sICAM -1)水平与胃癌临床病理指标的关系 ,评价检测胃癌患者sICAM -1的临床意义。方法 :应用酶联免疫吸附法分别检测34例治疗前胃癌患者及20例正常人血清中可溶性细胞间粘附分子 -1的含量。结果 :胃癌组及正常人对照组血清sICAM -1含量分别为367 7±104 7ng/ml,236 9±74 3ng/ml,两者有显著差异(P<0 001)。胃癌患者按临床病理特征分组 ,肿瘤直径≥5cm组、高临床期别(Ⅲ～Ⅳ)组和淋巴结转移组的各组血清sICAM -1含量较其相应对照组显著提高。结论 :血清sICAM

Objective: To study the relationship between the serum soluble intercellular adhesion molecule-1 (sICAM-1) and the clinicopathological features, and to evaluate the possible prognostic significance of sICAM-1 concentration in gastric cancers Methods: Thirty-four patients with gastric cancer were prospectively evaluated The control group consisted of 20 healthy volunteers Serum concentrations of ICAM-1 of them all were measured by the quantitative sandwich enzyme immunoassay technique Results: The mean value of serum ICAM in patients with gastric cancer was 367 71+104 7 ng/ml and that of the control group was 236 9+74 3 ng/ml, and the difference was significant (P<0 001) The patients with the tumor size equal to or more than 5cm had significantly higher serum concentration of ICAM-1 than those with smaller ones (406 7+90 2ng/ml vs 319 9 +105 3 ng/ml) (P<0 01) Compared the early stage (Ⅰ～Ⅱ) patients with more advanced clinical stage patients (Ⅲ～Ⅳ), the latter had a higher level of sICAM-1 (397 1+102 4ng/ml vs 306 0 +82 3ng/ml) (P<0 05) There was also a statistically significant difference in sICAM-1 levels between patients with positive lymph node status and those without (403 6+99 7ng/ml vs 302 7+81 4ng/ml) (P<0 01) No relation was observed between the level of sICAM-1 and the grade of histological differentiation in patients with gastric cancer Conclusion: Evaluation of sICAM-1 concentration may be a valuable parameter for predicting the prognosis and degree of cancer in gastric cancer patients