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H3K9甲基化在白血病中的表观遗传调控 被引量：3

Epigenetic Regulation of Histone H3 Lysine 9 Methylation in Leukemia——Review
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摘要 近年来表观遗传学修饰在恶性肿瘤发生发展中的作用日益引起人们重视。白血病患者中存在着组蛋白修饰的异常,H3K9甲基化失平衡与白血病的发生发展相关。SUV39H1是第一个被发现的特异性H3K9甲基转移酶,催化H3K9甲基化从而参与异染色质形成及基因转录调控。通过纠正H3K9的甲基化异常,使高甲基化失活的抑癌基因再度表达,将有望为白血病的治疗提供新的靶点。本文就组蛋白H3K9甲基化如何影响基因转录调控、沉默基因表达及H3K9甲基化与白血病的关系进行了综述。 In recent years, the role of epigenetic modifications in tumorigenesis drawed more and more attentmn. The aberrant changes of histone modifications have been found in leukemias, whereby loss of balance in H3K9 methylation is associated closely with leukemogenesis. SUV39H1, the first described histone H3 lysine 9 methytransferase takes part in heterochromatin formation and gene transcription regulation. It could be a new target for leukemia therapy by correcting the aberrance of H3K9 methylation, inducing the reexpression of tumor suppressor genes. This review discusses how H3K9 methylation regulating gene transcription, silencing gene expression and its association with leukemia.
作者 赵婷 马旭东
机构地区 福建医科大学附属漳州市医院血液内科
出处 《中国实验血液学杂志》 CAS CSCD 北大核心 2012年第1期210-213,共4页 Journal of Experimental Hematology
基金 卫生部科学研究基金 福建卫生教育联合攻关计划项目资助(编号wkj2008-2-55) 福建医科大学科学研究发展专项基金计划资助项目(编号FZS08018) 漳州市科学研究发展计划基金资助项目(编号Z07014)
关键词 组蛋白甲基化 甲基转移酶 白血病 表观遗传学 histone methylation methyltransferase leukemia epigenetics
分类号 R733.7 [医药卫生—肿瘤]
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参考文献26

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二级参考文献35

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共引文献14

同被引文献58

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二级引证文献4

中国实验血液学杂志
2012年 第1期
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