曲美他嗪对不稳定心绞痛患者内皮功能及炎症因子水平的影响

Effects of Trimetazidine on plasma levels of TNF-α,IL-6,ET-1 and NO of UA patients

目的:观察曲美他嗪(TMZ)对不稳定型心绞痛(UA)患者内皮素(ET-1)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的影响。方法:不稳定心绞痛患者82例,随机分为观察组和对照组,对照组接受常规抗心绞痛治疗,观察组在此基础上加用曲美他嗪片20 mg/次,每日3次,共12 w。治疗前、后抽取患者空腹静脉血保存备用。检测血浆中ET-1、NO、TNF-α和IL-6等细胞因子的表达水平。结果:与对照组比较,观察组患者血浆中ET-1、TNF-α和IL-6水平下降以及NO的升高更明显(P<0.05)。结论:采用TMZ治疗能改善UA患者的内皮功能,强化抗炎作用。

Objective：To observe the effects of Trimetazidine on plasma levels of endothelin（ET-1）,nitric oxide（NO） and tumor factor-α（TNF-α）,interleukin-6（IL-6） in patients with unstable angina（UA）.Methods：A total of 82 cases were randomly divided into observation group and control group.Patients in the control group received conventional drug therapy against unstable angina,and patients in the observation group treated with Trimetazidine tablets 20mg / time（tid） on the basis of conventional drug therapy for 12 weeks.Pre-and post-treatment,double antibodies sandwich ELISA kit used to determine ET-1,TNF-α and IL-6 expression in the blood of patients.Results： The patients in the endothelial function index of blood ET-1,NO,and inflammatory cytokines TNF-α,IL-6 were significantly improved than the control group（P0.05）.Conclusions： Treating with TMZ in patients with UA,endothelial function can improve obviously,and TMZ have potential anti-inflammatory effects,which could reduce blood inflammatory cytokines TNF-α,IL-6 levels.