生理因素对纹状体多巴胺D_2受体表达的影响

The Influence of Physiologic Factors on the Expression of Striatal Dopamine D_2 Receptors

为了研究大鼠的品系、性别和年龄相关的体重因素对纹状体多巴胺 D2 受体表达的影响 ,用大鼠纹状体和 1 2 5 I- IBZM{ (S) - 3-碘 - 2 -羟基 - 6 -甲氧基 - N-〔(1 -乙基 - 2 -吡咯烷基 )甲基〕苯甲酰胺 }结合 ,按照大鼠的品系、性别和年龄相关的体重进行组间配对比较。结果 :大鼠的品系和性别对纹状体多巴胺 D2 受体的 1 2 5 I- IBZM结合无明显影响 ,但纹状体多巴胺 D2 受体的 1 2 5 I- IBZM结合却有体重相关性的减少。由此表明 ,纹状体多巴胺 D2 受体可能具有年龄依赖性的减少。因此 。

The aim of this study was to know whether the strain, sex, and age related body weight of rat have influence on the expression of striatal dopamine D 2 receptor. The data on striatal dopamine D 2 receptor binding 125 I IBZM in 34 rats were used in the comparison between pairs of groups matched on strain, sex, and body weight. The result showed that the strain and sex of rats had no influence on the striatal dopamine D 2 receptor binding 125 I IBZM, but there was a body weight related decrease in the striatal dopamine D 2 receptor binding 125 I IBZM.The results suggest that age dependent decline of striatal dopamine D 2 receptors is possible; therefore, strict age matching is necessary to clinical studies.