功能性消化不良患者胃膨胀感知的改变

The change of stomach perception in the patients with functional dyspepsia

目的研究功能性消化不良（ＦＤ）患者胃膨胀感知的改变。方法应用灌注导管测压仪研究了７例ＦＤ患者、５例ＦＤ并心理异常患者及５例正常人胃对容量刺激的感觉。结果发现ＦＤ患者胃对容量刺激的最低敏感性阈值、不适阈值及疼痛阈值分别为（１９５．７±６５．３），（３０４．３±５８．６），（４６４．３±４７．２）ｍｌ，ＦＤ并心理异常患者为（１２３．０±４０．３），（２５４．０±４９．８），（４６６．０±７６．４）ｍｌ，均明显低于正常人的（３２７．０±４４．７），（５３２．４ ±１０７．４），（６７８．０±１１７．４）ｍｌ（Ｐ＜０．０１）；三者的胃顺应性无明显改变。结论胃对容量刺激的感知过度敏感是ＦＤ发病的机制之一。

Objective To investigate the change of stomach perception in patients with functional dyspepsia (FD). Methods Stomach perception to gastric distension was measured by using PC polygraph HR perfusion pressure measure systems in 7 cases of FD, 5 cases of FD with psychological abnormality and 5 healthy volunteers. Results The thresholds of minimal perception, uncomfortable feeling and painful feeling in FD were (195 .7 ±1 65.3), (304.3 ± 58.6), (464.3 ± 47.2) ml respec- tively in FD and (123 .0 ± 40.3), (254.0 ± 49.8), (466.0 ± 76.4) ml in FD with psychological abnormality, both significantly lower than those in normal control (327.0 ± 44.7), (532.4 ± 1 .7 .4) and (678.0 ± 117.4)ml (P < 0.01) .There was no differ- ence in gastric compliance among 3 groups. Conclusion Hyporsensitivity of stomach perception plays an important role in the etiology of FD.