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雨虎属Ras同系物-Ⅰ基因及其与口腔肿瘤间的关系

Relationship between tumor suppressor genes Aplysia Ras homolog-Ⅰ and oral cancer
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摘要 雨虎属Ras同系物(arh)-Ⅰ基因参与细胞周期调控和信号通路的传导,从而负向调节细胞生长和诱发程序性细胞死亡。arh-Ⅰ基因在卵巢、乳腺和胰腺等癌细胞中均有表达缺失,即arh-Ⅰ基因与肿瘤的形成和发展密切相关。本文就arh-Ⅰ基因的定位与结构、作用途径和与肿瘤间的关系等研究进展作一综述。 Aplysia Ras homologues （arh）- I genes involved in cell cycle regulation and signaling pathways of transmission, thus the negative regulation of cell growth and induce programmed cell death, arh- I gene in ovarian, breast and pancreas cancer cells in both the loss of expression, arh- I gene and tumor formation and development are closely related. This article on the arh-I gene location and structure, mechanism and relationship with cancer research are reviewed.
作者 张雪 李一军 陈英新
机构地区 第四军医大学口腔医院综合科 吉林大学口腔医院VIP综合科
出处 《国际口腔医学杂志》 CAS 2012年第2期224-225,229,共3页 International Journal of Stomatology
基金 吉林省科技厅综合计划基金资助项目(200705346)
关键词 雨虎属Ras同系物-Ⅰ 甲基化 口腔肿瘤 Aplysia Ras homolog-I methylation oral tumor
分类号 R739.8 [医药卫生—肿瘤]
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参考文献13

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二级参考文献12

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共引文献16

国际口腔医学杂志
2012年 第2期

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