玉溪市2010年儿童手足口病的病原学监测分析

Etiology Survey of Hand Foot and Mouth Disease in Yuxi in 2010

目的对玉溪市2010年1～12月手足口病流行时期该病患儿进行病原学调查,了解导致流行的肠道病毒感染情况.方法采用逆转录荧光聚合酶链反应(Fluorescence RT-PCR)方法,对238例临床诊断为手足口病患儿的咽拭子标本进行肠道病毒71型和柯萨奇病毒A16型RNA的检测.结果检测结果 73份标本为阳性,阳性检出率为30.67%.其中41例患儿为CoxA16阳性,32例患儿EV71阳性.结论所检测2010年玉溪市儿童手足口病流行以CoxA16感染和EV71为主,CoxA16和EV71感染患儿的表现相似,临床难以鉴别,重症病例以EV71感染为主;普通病例以CoxA16感染为主.

Objective To investigate the the etiology of hand foot and mouth disease in children from January to December of 2010 in Yuxi, and to learn the epidemics of enterovirus infections. Method Fluorescence RT-PCR was used to detect the RNA of EV71 and CoxA16 in 238 specimens of throat swabs from patients with HFMD. Results 73 patients were identified as positive by the rate of 30.67%. 32 patients were infected by EV71, 41 patients were infected by CoxA16. Conclusions The major causes of HFMD in this epidemic are CoxA16 and EV71. EV71 causes the severe cases. On the parallel CoxA16 causes the general cases.