精神分裂症患者性激素与认知功能的关系

The relationship between sex hormones and cognitive function in schizophrenia

目的:探讨精神分裂症患者性激素与认知功能的关系。方法:精神分裂症患者95例,使用利培酮治疗6周,分别于治疗前和治疗后进行雌二醇(E2)、孕酮(Prog)、睾酮(T)、催乳素(PRL)、促卵泡激素(FSH)、黄体生成素(LH)检测、简明精神病评定量表(BPRS)评定和瑞文标准推理测验。结果:男性患者的E2、T、FSH、LH水平与瑞文测验正确题数、知觉辨别、类同比较、比较推理、系列关系正确题数均正相关;治疗后E2、T水平不再与瑞文推理测验相关。女性患者的E2、Prog、T、FSH、LH水平与瑞文测验正确题数、智商数、类同比较、比较推理、系列关系、抽象推理正确题数均正相关;治疗后E2、LH水平仍与瑞文测验正确题数、智商数、类同比较、比较推理、系列关系、抽象推理正确题数正相关,T水平与瑞文测验正确题数及所有因子正确题数负相关。结论:男女精神分裂症患者性激素对认知功能有不同影响。

Objective： To investigate the relationship between sex hormones and cognitive function in schizophrenia. Method ： 95 schizophrenia cases, receiving 6-week risperidone treatment were involved, and estradiol （ E2 ） , progesterone （Prog） , testosterone （T） , prolactin （PRL） , follicle-stimulating hormone （ FSH ） , luteinizing hormone （LH） test, brief psyehiatrid rating scale（BPRS） assessment and Raven tests were conducted before and after treatment. Results： Male patients＂ E2, T, FSH, LH levels were positively related to the correct number, perceiption discrimination, similarity comparison, comparison reasoning, series relations on Raven test. After treatment, E2 and T levels were no longer related to the Raven test. Female patients＂ E2, Prog, T, FSH, LH levels were positively related to the correct number, intelligence quotient, similarity comparison, comparison reasoning, series relations, abstract reasoning ; after treatment, E2, LH levels were remain positively re- lated to the correct number, intelligence quotient, similarity comparison, comparison reasoning, series relations, abstract reasoning,T level was negatively related to the correct number and each factor score. Conclusion： The sex hormones of male and female schizophrenia have different effects to cognitive function.