摘要
本文对55例肝病患者、带乙肝病毒者和30例无肝病对照者的肝、胰组织作HBsAg、HBcAg免疫组织化学(PAP法)检查。结果在18例胰、49例肝中查到HBsAg。其中,肝硬化组31例中肝29例(93.5％)、胰12例(38.9％)阳性;肝带病毒组8例中胰含HBsAg者3例(37.5％);重症肝炎组16例中肝带有HBsAg者12例(75％),胰含HBsAg者1例(6.3％);无肝病的对照组30例中胰含HBsAg者2例(6.7％)。前2组胰带HBsAg显著高于后2组,提示肝内含HBsAg的慢性肝病患者及免疫力低的带病毒者乙肝病毒较易侵犯胰组织。乙肝病毒在胰中可复制。胰腺中的乙肝病毒可能通过某种机制引起慢性胰腺炎。
By means of immunoperoxidase technique(PAP)HBsAg was detected in 12/31(38.7%)of the pancreas of hepatic cirrhosis,in 29/31 of the liver and in 3/8(37.5%)of the pancreas of chronic HBsAg carriers.The positive rate of the pancreas of these two groups were distinctly higher than those groups of fatal hepatitis(1/16)and non—hepatopathic control(2/30).Probably,prolonged HBV infection and/or low immunity are important in the pancreatic involvement.HBsAg in the pancreas was often lesser in amount than in the liver,and was often limited to several exocrine acinous cells.The islets were involved occasioually,only one or two islets per section were positive.4 cases showed HBpAg in the pancreas in 12 HBsAg positive hepatic cirrhosis,and none in the other groups.It is noteworthy that 3 cases with HBsAg in pancreas showed distinct chronic interstitial pancreatitis microscopically i.e.mononuclear cellular infiltration,fibrosis and a decrease of acinous tissue.
