卵巢肿瘤的雌孕激素受体研究

RESEARCH ON ESTROGEN RECEPTORS AND PROGESTERONE RECEPTORS IN HUMAN OVARIAN TUMOR

本研究采用组织化学法测定了38例卵巢肿瘤的雌、孕激素受体,发现少数良性肿瘤、部分恶性肿瘤组织中存在雌、孕激素受体,且恶性肿瘤的雌激素受体的阳性率高于良性肿瘤。恶性肿瘤中上皮类肿瘤的雌、孕激素受体阳性率高于非上皮类肿瘤,分化好的肿瘤的雌激素受体高于分化差的肿瘤。雌、孕激素受体的阳性率与临床期别、月经状况无关。本研究提示:雌、孕激素受体作为指导卵巢肿瘤内分泌治疗和预测预后提供了一定的理论根据。

Estrogee receptors(ER)and progesterone receptors(PR)were measured in 24 malignant and 14 benign ovarian tumors.Estrogen receptors and progesterone receptors were found in a few benign tumors and in several malignant ovarian tumors.Also,ER positive rate in the malignant tomors was higher than that of the benign tumors.ER and PR positive rates in the epithelial tumors were higher than those,of the non-epithelial tumors.Highly differentiated malignant tumors possessed more ER than that of the poorly differentiated malignant tumors.But,on such difference was found in the PR.The number of receptors was not related to the clinical stage and the state of mensturation.This study suggests that measurements of ER and PR are of value in determining.the prognsis of the ovarian cancer,and givean indication for their endocrine therapy.