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抗苗勒管激素与多囊卵巢综合征的相关性的研究进展 被引量：4

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摘要 抗苗勒管激素（Anti-Mullerian hormone,AMH）是一种二聚体糖蛋白。人类AMH基因位于19号染色体短臂,含有5个外显子,编码560个氨基酸的蛋白前体,经水解释放的12kb羧基末端二聚体才具有促进苗勒管退化生物活性并能抑制某些肿瘤的生长与分化。AMH与抑制素（Inhib-ins）、
作者 孟腾腾 谢铁男 李春洪
机构地区 吉林大学白求恩第一医院生殖医学中心 吉林大学白求恩第一医院妇产科
出处 《中国实验诊断学》 2012年第2期376-377,共2页 Chinese Journal of Laboratory Diagnosis
关键词 抗苗勒管激素 多囊卵巢综合征 相关性 9号染色体 蛋白前体 生物活性 羧基末端 二聚体
分类号 R711.75 [医药卫生—妇产科学]
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参考文献21

  • 1DurlingerAL,Visser JA,Themmen AP.Regulation of ovarian function:the role of ant[J].Rep roduction,2002,124(5):601.
  • 2Di ClementeN,Wilson C,Faure E,et al.Cloning,expression,and alternative splicing of the receptor for anti-Mü llerian hormone[J].Mol Endocrinol,1994,8(8):1006.
  • 3Diamanti-Kandarakis E,Kouli C,Tsianateli T,et al.Therapeuticeffects of metformin on insulin resistance and hyperandrogenis m in polycystic ovary syndr ome[J].Eur J Endocrinol,1998,138:269.
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  • 5Weenen C,Laven JS,Von Bergh AR,et al.Anti2 mü llerian hormone expression pattern in the human ovary:potential implications for initial and cyclic follicle recruitment[J].Mol Hum Rep r od,2004,10(2):77.
  • 6Pellatt L,Hanna L,BrincatM,et al.Granulosa cell p roduction of anti -Müllerian hormone is increased in polycystic ovaries[J].J Clin Endocrinol Metab,2007,92(1):240.
  • 7Sir-Petermann T,MaliqueoM,Codner E,et al.Early metabolic derangements in daughters of women with polycystic ovary syndrome[J].J Clin Endocrinol Metab,2007,92 (12):4637.
  • 8Pigny P,Merlen E,Robert Y,et al.Elevated serum level of anti-Mullerian hormone in patients with polycystic ovary syndrome:rela2tionship to the ovarian follicle excess and to the follicular arrest[J].J Clin Endocrinol Metab,2003,88 (12):5957.
  • 9LaMarca A,Orvieto R,Giulini S,et al1 Mullerian inhibiting substance in women with polycystic ovary syndrome:relationship with hormonal and metabolic characteristics[J].Fertil Steril,2004,82(4):970.
  • 10Pigny P,Merlen E,Robert Y,et al.Elevated serum level of anti mullerian hormone in patients with polycystic ovary syndrome[J].J Clin Endocrinol Metab,2003,88(12):5957.

二级参考文献21

  • 1Visser JA, Olaso R, Verhoef-Post M, et al. The serine / threonine transmembrane receptor ALK2 mediates Mullerian inhibiting substance signaling [J]. Mol Endocrinol, 2001, 15 (6): 936-945.
  • 2Jamin SP, Arango NA, Mishina Y, et al. Genetic studies of the AMH/MIS signaling pathway for Mullerian duct regression [J]. Mol Cell Endocrinol, 2003, 211(1/2):15-19.
  • 3Nilsson E, Rogers N, Skinner MK. Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition [J]. Reproduction, 2007, 134(2): 209-221.
  • 4Durlinger AL, Gruijters M J, Kramer P, et al. Anti-mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary [J]. Endocrinology, 2001, 142( 11 ): 4891-4899.
  • 5Catteau-Jonard S, Pigny P, Reyss AC, et al. Changes in serum anti-mullerian hormone level during low-dose recombinant follicularstimulating hormone therapy for anovulation in polycystic ovary syndrome [J]. J Clin Endocrinol Metab, 2007, 92(11): 4138-4143.
  • 6Pellatt L, Hanna L, Brincat M, et al. Granulosa cell production of anti-mullerian hormone is increased in polycystic ovaries [J]. J Clin Endocrinol Metab, 2007, 92( 1 ): 240-245.
  • 7Rooij IA, Frank JM, Scheffe GJ. Serum anti-mullerian hormone levels best refect the reproductive decline with age in normal women with proven fertility: alongitudinal study [J]. Fertil Steril, 2005, 83(4): 979-987.
  • 8Fanchin R, Schonauer LM, Righini C, et al. Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3[J]. Hum Reprod, 2003, 18(2): 323-327.
  • 9La Marca A, Giulini S, Tirelli A, et al. Anti-Mullerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology [J].Hum Reprod, 2007, 22(3): 766-771.
  • 10Ficicioglu C, Kutlu T, Baqlam E, et al. Early follicular anti- Mullerian hormone as an indicator of ovarian reserve [J]. Fertil Steril, 2006, 85(3): 592-596.

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同被引文献33

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二级引证文献22

中国实验诊断学
2012年 第2期

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