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糖基化磷脂酰肌醇锚定蛋白转化法——一门全新的细胞表面工程学 被引量:3

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摘要 糖基化磷脂酰肌醇(GPI)锚定蛋白是一种新型细胞表面蛋白,它只通过GPI结构锚定于细胞膜表面而不跨越其磷脂膜双层结构;当它与细胞共同孵育时,可自动整合至细胞膜表面。GPI锚定蛋白转化法利用GPI锚定信号将目的蛋白直接整合至靶细胞表面,超越了目的蛋白由靶细胞自身合成的机制,具有对靶细胞选择性不高,转化过程迅速等优点,在抗原提呈细胞工程、肿瘤疫苗及移植物抗排斥反应等研究领域得到了广泛应用。
出处 《国外医学(分子生物学分册)》 CSCD 2000年第2期105-108,共4页
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参考文献10

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同被引文献21

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