手性农药毒性评价进展

Progress in potential toxicity of chiral pesticides

长期以来,手性农药都被当作单一化合物进行环境行为和生态毒性研究,但是由于手性农药对映体与生物大分子相互作用的立体选择性,手性农药对动物及人类的毒性作用可能具有对映体选择性.本文介绍了有机磷、有机氯、拟除虫菊酯、苯基吡唑等手性农药对内分泌、神经、免疫、生殖、发育等毒性作用的对映体选择性,分析了对映体选择性产生的机制,在此基础上提出了未来的研究方向.

In the past,chiral pesticides were explored as racemic mixtures in environmental fate and ecotoxicities.However,as a result of the enantioselective interactions with chiral molecules,the enantiomers of chiral pesticides may have different potential toxicities to humans and animals.The present review introduced recent findings on enantioselective endocrine disruption,neurotoxicity,immunotoxicity,reproductive and developmental toxicity of organophosphorus,organochlorines,pyrethroids and phenylpyrazole pesticides,as well as the underlying mechanisms.Furthermore,the developmental trends of future investigations were discussed.