143例含莫西沙星化疗方案治疗首次复阳肺结核临床研究

Clinical Research of Moxifloxacin on First-time Retreatment of 143 Cases of Sputum-positive Pulmonary Tuberculosis

目的观察和评价莫西沙星治疗首次复阳肺结核的疗效和安全性。方法 152例首次复治菌阳肺结核患者随机分为治疗组(n=79)和对照组(n=73)。化疗方案均应用2HREZ/4HR(H异烟肼、R利福平、E乙胺丁醇及Z吡嗪酰胺),治疗组在此基础上加用莫西沙星,对照组应用左氧氟沙星,按各自方案实施6个月短化治疗。结果疗程结束时,治疗组及对照组的痰菌阴转率分别为95.89%、74.29%,两组对比差异有统计学意义(P<0.05);病灶吸收总有效率为97.26%、84.29%,两组对比差异有统计学意义(P<0.05)。结论应用含有莫西沙星方案治疗首次复阳肺结核,有助于痰菌阴转及病灶吸收好转,可以临床推广应用。

Objective To observe and evaluate the efficacy and safety of moxifloxacin on the first - time retreatment of sputum- positive pulmonary tuberculosis. Methods One hundred and fifty- two first - time retreated sputum - positive pulmonary TB patients were randomly divided into therapy group （n = 79） and control group （n = 73）. The chemotherapy regimen was 2HREZ/4HR for six months. Based on the same chemotherapy regimen, therapy group was additionally given moxifloxacin and control group additionally received ofloxacin. Results At the end of chemotherapy, the sputum negative conversion rates of therapy group and control group were 95.89% and 74.29%, respectively; and the difference was statistically significant be- tween the two groups （P 〈0.05）. The total effective rates of radiographic improvement in therapy group and control group were 97.26 % and 84.29 %, respectively; and the difference was statisticallysignificant between the two groups （P 〈0.05）. Conclusions Applying the scheme of moxifloxacin in the first - time retreatment of sputumpositive pulmonary tuberculosis is con- ducive to sputum negative conversion and lesion absorption. It is worthy of being applied widely in the clinical practice.