小剂量持续胃肠透析治疗尿毒症临床观察

EFFECT OF CONTINUOUS GASTROINTESTINAL DIALYSIS WITH LOW DOSAGE DIALYSATE IN UREMIC PATIENTS

目的：观察小剂量持续胃肠透析治疗尿毒症的效果。方法：５８例尿毒症患者随机分为两组，治疗组口服胃肠透析液，每次１０００ｍｌ，每天３次，对照组口服包醛氧化淀粉，每次５－１０ｇ，每天３次，疗程３个月。结果：与治疗前及对照组相比，小剂量持续胃肠透析治疗后，患者的临床症状改善，生活质量提高，营养状况良好，血肌酐，尿素氮，血磷，血尿酸水平明显下降，内生肌酐清除率水平明显升高。

Objective:To investingate the effect of continuous low dosage gastrointestinal dialysis in uremic patients.Methods:Fifty-eight patients with uremia were divided into two groups at random,the treatment group in which thirty patients were given one litre non-absorbed mannitol solution three times a day and the control group in which twenty-eight patients were given five or ten gramme Coated Aldehyde Oxystarch three times a day.The observing time was three months.Results:There were significant improvement of uremic symptoms,living quality and nutritional satatus,significant reductions of serum creatinine\,blood urea nitrogen\,serum phosphorus and uric acid,significant increment of creatinine clearance after one and three months in the treatment group respectively.It was significant to compare with the control group (P<0.01).No significant change of above parameters were seen in the control group.Either in treatment group or control group,no significant changes in blood pressure\,body weight\,total plasma protein\,serum albumin\,proteinuria and urine amout were observed.Conclusion:The effect of continuous low dosage gastrointestinal dialysis in uremic patients was obvious.It added a new methed to treat CRF with non-replacement therapy.