慢性乙型病毒性肝炎患者血清可溶性细胞间粘附分子-1水平与干扰素疗效的关系

Relationship between the serum soluble intercellula adhesion molecule 1 levels and response to interferon α-1b in patients with chronic hepatitis B

目的 探讨慢性乙型病毒性肝炎患者血清可溶性细胞间粘附分子 1 (sICAM 1 )水平变化和干扰素疗效的关系。方法 对 1 8例慢性乙型病毒性肝炎患者干扰素治疗前、治疗后 3个月、6个月的血清sICAM 1、肝功能、HBVM进行检测。结果 1 8例患者中 1 0例完全或部分有效 ,有效率 1 0 1 8(55 6 % )。1 0例有效者治疗后血清sICAM 1水平明显下降 ,而无效组则无明显变化。结论 干扰素治疗有效者血清sICAM 1明显下降 。

Objective To study the reletionship the between change of serum levels of soluble intercellular adhesion moleculc 1 (sICAM 1)and the response to interferon α 1b in patients with chronic hepatitis B.Methods Serum sICAM 1 HBsAg antiHBs HBeAg anti HBe anti HBc were measured with ELISA and HBVDNA were determined by PCR from 18 patients with chronic hepatitis B before treatment ,in three months after treatment and in six months with interferon α Ib.Results Partial or complete responses to therapy were achieved in 10 of 18 patients with chronic hepatitis B.Serum sICAM 1 levels fell significantly in 10 responders out of 18 patients treated with interferon α 1b,whereas levels remained unchanged in the non responder group.Conclusion Serum sICAM 1 levels fall with successfull interferon treatment in patients with chronic hepatitis B.Thus,a fall in serum sICAM 1 levels can be used as a marker of interferon response.