摘要
目的观察骨新康对卵巢切除致大鼠骨质疏松症的治疗作用。方法选用SD雌性大鼠,随机分为7组,每组12只,一组切去腹腔中少量脂肪作为假手术组,其余各组大鼠切除双侧卵巢,3个月后各组干预给药,8周后测定各组股骨骨密度、骨生物力学指标、骨显微结构,以及大鼠血清生化指标。结果骨新康具有增加骨密度、改善骨生物力学指标以及具有性激素和促性腺激素样作用。结论该药物具有抗大鼠骨质疏松症的作用。
Objective To investigate the effects of Guxinkang on osteoporosis in rats after ovariectomy （OVX）. Methods SD female rats were randomly divided into seven groups with 12 in each group. The control group by cutting adipose tissue was Sham group, while the rats in other groups received bilateral OVX. After three months of surgery, Guxinkang was given to the rats for extra two months. The levels of bone density, bone biomechanics, blood calcium, blood phosphorate, and bone microstruc^tre were observed in each group. Results Compared with the model group, Guxinkang could significantly increase the bone density, bone biomechanics, blood calcium, and the microstructure of bone trabecular width with hormone and gonadotropin-like action. Conclusion Guxinkang has a distinct preventive and effect on osteoporosis of rats.
出处
《药物评价研究》
CAS
2012年第1期14-17,共4页
Drug Evaluation Research
关键词
骨新康
骨质疏松
卵巢切除
Guxinkang
osteoporosis
ovariectomy （OVX）
