邻苯二甲酸二乙基己酯(DEHP)毒理与健康效应研究进展

Research Advances in Toxicology of DEHP and Its Health Effects

邻苯二甲酸二乙基己酯(DEHP)作为重要的聚氯乙烯塑料增塑剂在工业上应用广泛。目前,DEHP在海洋、大气、饮用水及动植物体内均被不同程度检出,对生态环境造成日益严重的污染。结合国内外毒理学研究成果,概述DEHP的人体暴露及代谢途径;并从肝脏、心脏、生殖发育系统和呼吸系统等方面详细探讨DEHP对动物健康的危害及其可能的毒性机制,以及对人体健康潜在的影响;在此基础上,对目前存在的问题及进一步研究的方向进行了探讨和展望。

Proteomic technologies, the important tools in post-genome era, have greatly promoted the development of aquatic toxicology. This review was dedicated to the recent development and application of proteomic technologies in aquatic toxicology. The development of proteomic research methods were fully introduced in terms of protein extraction, separation, identification and quantification, which especially focused on the introduction and comparison of gel-based and gel-free proteomic techniques as the main two protein separation and identification methods. The application of proteomic technologies in aquatic toxicology were summarized in details from the perspectives of identification and quantification of proteins, functional modifications of proteins, and protein-protein interactions, such as studies on toxicological mechanism of water pollutants, and the monitoring and evaluation of water pollution. Finally, problems of present proteomic research were pointed out and suggestions were accordingly given for future proteomic studies in aquatic toxicology.