摘要
目的:阐明豨莶草抗风湿作用机理。方法:建立佐剂性关节炎(adjuvant arthritis,AA)大鼠模型。观察豨莶草活性部位对AA大鼠淋巴细胞增殖反应、白细胞介素一1(IL-1)、白细胞介素一2(IL一2)活性的影响,并同时观察AA大鼠踝关节病理切片,以及豨莶草的镇痛作用。结果:豨莶草可减轻AA大鼠踝关节炎症等病理反应;有较好的镇痛作用,镇痛率为65%。豨莶草可增强AA大鼠T细胞的增殖功能,促进IL-2的活性,抑制IL-1的活性,与对照组比较有显著性差异(P < 0.01)。结论:豨荃草可通过调整机体免疫功能,改善局部病理反应而达到抗风湿作用。
To explore the mechanism of anti-rheumatism action of the active fraction of Herba Siegesbeckiae (AFHS). Methods: Adujvant arthritis model of rat was made to observe the effect of AFHS on lymphocyte proliferation, interleukin-1 (IL-1) and IL-2 activity, pathologic section of ankle joint, and analgesic effect of AFHS in model rat. Results: AFHS could reduce the inflammatory pathologic response of ankle joint, it functions well as analgesics, the analgesic rate being 65%, AFHS could also improve T-lymphocyte proliferation, improve IL-2 activity and inhibit IL-1 activity, as compared with the control group, the difference was significant (P< 0.01 ). Conclusion: Through regulating the immune function of organism, AFHS could improve the local pathologic response so as to antagonise against rheumatism, therefore, it is a good anti-rheumatism herbal medicine.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2000年第3期192-195,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家重点科技项目攻关计划基金!( NO. 96- 903- 02- 02)