摘要
目的:血清N-末端脑钠肽前体(N-terminal-pro-B-type natriuretic peptide,NT-proBNP)为诊断心功能衰竭的特异性生物学指标。由于肾脏清除率降低可使NT-proBNP的清除减少,而使肾功衰竭的患者血清NT-proBNP水平升高。本文NT-proBNP水平评估慢性肾脏疾病患者左心室功能。方法:收集慢性肾脏疾病患者60例(男44,女16),检测其左心室射血分数(left ventricular ejection fraction,LVEF),体重指数(body mass index,BMI),血清肌酐(creatinine,Cr),NT-proBNP。结果:NT-proBNP与BMI、年龄、性别均显著相关。NT-proB-NP水平为150.0pg/ml和510.0pg/ml,在诊断慢性肾脏疾病患者左心室功能紊乱的敏感度、特异度分别为93.5%、29.2%和53.2%、88.1%。结论:NT-proBNP水平在510.0pg/ml时对慢性肾脏疾病患者发生心功能衰竭有良好的预测价值。
Objective The level of NT-proBNP（ N-terminal-pro-B-type natriuretic peptide） is used as a predictor in the diagnosis and management of heart failure. For the diminished renal clearance of NT-proBNP , its level elevated in kidney failure. This study evaluated the NT-proBNP prognostic value for assessing ventricular function in patients with chronic kidney disease. Methods 60 patients including 44 males and 16 femals were diagnosed with chronic kidney disease. Echocardiography was employed to assess ejection fraction. Body mass index（ BMI）, serum creatinine, NT-proBNP were measured for all the patients. Prognostic value of NT-proBNP was assessed for left ventricular （LV） function measured by ejection fraction （EF）. Results Level of NT-proBNP had a significant cor- rection with BMI, LVEF, age, and gender. The sensitivity and specificity of NT-proBNP levels of 150.0 pg/ml and 510.0pg/ml were 93.5% and 29.2% and 53.2% and 88.1%, respectively, for the diagnosis of ventricular dysfunction in the patients with chronic kidney disease. Conclusion These findings suggest that a level of NT-proBNP of 510.0 pg/ml is a rather acceptable predictive factor for heart failure in patients with chronic kidney disease.
出处
《放射免疫学杂志》
CAS
2012年第1期58-60,共3页
Journal of Radioimmanology
