糖尿病肾病患者外周神经传导速度的变化

Change of perinerve conduction velocity in patients with diabetic nephropathy

目的分析影响２型糖尿病外周神经传导速度的因素，比较合并糖尿病肾病（ＤＮ）与未合并ＤＮ患者的外周神经传导速度的差异。方法检测６３例２型糖尿病患者左正中神经、左腓总神经的运动神经传导速度（分别为ＭＣＶ１、ＭＣＶ２），左正中神经的感觉神经传导速度（ＳＣＶ），同时测定ＦＢＧ、ＨｂＡ１Ｃ和晨尿白蛋白（ＭＡＣ），按ＭＡＣ的水平确定有无ＤＮ并分组，分别统计两组的ＭＣＶ１、ＭＣＶ２、ＳＣＶ。结果ＭＣＶ１、ＭＣＶ２、ＳＣＶ分别与ＨｂＡ１Ｃ、ＭＡＣ水平呈负相关，与年龄无关。ＭＣＶ１、ＭＣＶ２与病程呈负相关。合并ＤＮ者外周神经传导速度较未合并ＤＮ者减慢，两者比较有显著性差异。结论２型糖尿病患者外周神经传导速度与ＨｂＡ１ｃ、ＭＡＣ呈负相关，合并肾脏病变的糖尿病患者常同时合并外周神经病变。

Objective To analyze factors effecting perinerve conduction velocity in type I diabetes mellitus and compare perinerve conduction velocity between patients with DN and those without DN. Methods 63 cases of type 2 diabetes mellitus were enrolled. Their motor nerve conduction velocity of left median nerve(MCV1) and left common peroneal nerve(MCV2), sensory conduction velocity of left median nerve (SCV),FBG, HbA1C and MAC were tested. Results MCV1, MVC2 and SCV had negative relationship with HbA1c and MAC. The perinerve conduction velocity in patients with DN were significantly lower than that in patients without DN. Conclusion Perinerve conduction velocity in type 2 diabetes mellitas has negative relationship with HbA1C and MAC. Diabetic patients with nephropathy usually company perinerve.