智能纳米水凝胶的制备及其刺激响应性能和应用研究进展

Progresses in Investigation of Preparation,Stimulus Responsive Properties and Application of Intelligent Nano-Hydrogels

粒径为1～1 000 nm的智能纳米水凝胶是近年来受到国内外普遍关注的智能聚合物纳米材料。介绍了制备智能纳米水凝胶的4种方法:沉淀聚合/交联法、反相乳液聚合/交联法、自组装/交联法和微模板成型/交联法,评述了这些制备方法的优缺点;同时论述了温度、pH、光、磁场和分子识别等单刺激响应性智能纳米水凝胶以及多重刺激响应性智能纳米水凝胶的研究进展情况;最后简单介绍了智能纳米水凝胶在药物输送与可控释放、医学诊断、生物传感器、智能微反应器和吸附与分离等方面的应用。

Intelligent nanogels with particle diameters ranging from 1 to 1 000 nm are the intelligent polymer nanomaterials which have attracted widespread attention all over the world. In this paper, four kinds of methods for preparing the intelligent nanogels（precipitation polymerization/crosslinking method, inverse emulsion polymerization/crosslinking method, self-assembly/crosslinking method and micromoulding/crosslinking method） are firstly introduced, and their advantages and disadvantages are assessed. Then, the research progress on temperature, pH, light, magnetic field or molecule recognition stimulus responsive intelligent nanogels and multi-stimuli responsive intelligent nanogels are reviewed combining our research work. Finally, some application examples of the intelligent nanogels in drug delivery and controlled release, medicine diagnosis, biosensor, intelligent micro- reactor and adsorption separation are offered.