理脾化痰降脂片对高脂血症患者脂类代谢酶的影响

Effect of Lipi Huatan Jiangzhi Tablet on Lipid Metabolic Enzymes in Hyperlipemia

为进一步明确理脾化痰降脂片 (由太子参、法半夏、白术、茯苓、草决明、莱菔子、绿茶、丹参等中药组成 )的调脂作用机理 ,采用分层随机法将 80例高脂血症患者分为理脾化痰降脂片治疗组 (简称治疗组 ) 50例 ,力平脂对照组 (简称对照组 ) 30例。用单盲法进行临床观察和检测患者治疗前后脂蛋白脂酶(LPL)、卵磷脂胆固醇酰基转移酶 (LCAT)的活性。结果 :理脾化痰降脂片可显著地升高LPL、LCAT的活性 (P <0 .0 5或P <0 .0 1)。提示升高脂类代谢酶的活性可能是理脾化痰降脂片调脂的作用机理之一。

To further study the mechanism of Lipi Huatan Jiangzhi Tablet (LHJT) for regulating blood lipids,a single_blinded controlled clinical trial was carried out.Eighty cases of hyperlipemia were randomly allocated by stratification to LHJT group (50) and lipanthyl control group (30).The activities of lipoprotein lipase(LPL)and lecithin_cholesterol acyltrans_ferase (LCAT) were examined before and after treatment.The results showed that LHJT could significantly raised the activities of LPL and LCAT (P< 0.01 or P< 0.05 ). It is suggested that the enhancement of activity of lipid metabolic enzyme may be one of the lipid_reducing mechanisms of LHJT.