阻塞性睡眠呼吸暂停低通气综合征与抑郁症相关性

Relationship between obstructive sleep apnea hypopnea syndrome and depression

目的探讨不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与抑郁症的关系。方法 88例OSAHS患者根据睡眠呼吸混乱指数(AHI)及夜间最低血氧饱和度被分为轻度、中度及重度组。所有的受试者都接受Zung抑郁自评量表(SDS):包括20项题目,用以评定受试者的抑郁症状,SDS粗分乘以1.25为标准分,以标准分≥50为存在抑郁症状。比较各组之间抑郁症的患病率。结果对照组与OSAHS组的年龄、体重指数差异无统计学意义,但OSAHS组患者的AHI明显高于对照组;而夜间最低血氧饱和度明显低于对照组,此外OSAHS组抑郁的发生率为47.72%,显著高于对照组的13.33%。结论重度OSAHS患者比中度OSAHS患者患抑郁症的几率高,中度OSAHS患者比轻度OSAHS患者抑郁症的几率高,随着病情的逐渐加重,抑郁症的发病率明显增高。因此,及时诊断及治疗OSAHS有利于防止抑郁症的发生。

Objective To Explore the relationship between different degree obstructive sleep apnea hypopnea syndrome（OSAHS） and depression. Methods Eighty-eight patients with obstructive sleep apnea were divided into mild,moderate or severe group based on AHI and the lowest blood oxygen saturation at night. All subjects underwent Zung depression self rating scale （SDS）：including 20 items subject to evaluate the subjects symptoms of depression was multiplied by 1.25 points for the SDS standard score. Standard score ≥50 for existence depressive symptoms. Comparison the prevalence of depression in groups. Results There was statistically insignificant in age,body mass index between control group and OSAHS group ,but AHI of OSAHS patients significantly higher than those in the control group; And the lowest blood oxygen saturation at the night was significantly lower than the control group,in addition,incidence of depression was 47.72% in OSAHS group,and significantly higher than those in the control group （13.33%）. Conclusion Severe OSAHS patients have higher risk of depression than moderate OSAHS patients,moderate OSAHS patients have higher risk of depression than patients with mild OSAHS,the incidence of depression significantly higher when condition is more server. Therefore,OSAHS patients received timely treatment can used to prevent the occurrence of depression.